Benzinga's Top #PreMarket Losers

Tonix Pharmaceuticals Holding

shares slipped 56.45% to $6.08 in pre-market trading after the company reported Phase 2b BESTFIT trial of TNX-102 SL in patients with fibromyalgia. The study did not meet primary endpoint. Shire plc

dropped 1.41% to $258.94 in pre-market trading after rising 3.15% on Friday. Mattel

fell 1.36% to $30.39 in pre-market trading. Analysts at MKM Partners downgraded Mattel from Buy to Neutral and lowered the target price from $41 to $32. BlackBerry

shares dropped 1.36% to $10.12 in pre-market trading. On Friday, BlackBerry reported a narrower-than-expected second-quarter loss. However, the company's revenue missed analysts' estimates.