Rich Cimini's pick: This is a tough spot for Sam Darnold, who will be without at least two key weapons in Quincy Enunwa and Bilal Powell. Darnold, who has a league-high 10 interceptions, will be facing a defense that has 17 takeaways, second in the NFL. The Jets are also a lousy road team, having lost nine of their past 11. Bears 31, Jets 17
Jeff Dickerson's pick: Khalil Mack's right ankle remains an issue, but Chicago's defense still has a clear edge over Darnold. It is tied for first in the NFL with 11 interceptions. Darnold, on the other hand, is coming off a three-pick performance last week against the Vikings. The Bears are far from perfect on offense, but as long as they clean up their mistakes on special teams, Chicago's superior overall talent propels them to victory. Bears 29, Jets 24
FPI win projection: CHI, 76.2 percent. The best Total QBR in the NFL over the past four weeks belongs to none other than Mitchell Trubisky, who has an 87.1 over that span. But he might have a tough time keeping that up against a Jets defense that ranks third in the NFL in opponent Total QBR (49.7) this season.
What to watch for in fantasy: Three fantastic games in a row have made Tarik Cohen a safe RB2. Read more.
In case you missed it: Darnold's growth could be stunted by Jets' mounting injuries ... Bears look to climb out of NFC North cellar against Jets ... Jets exploring wide-receiver market, but it's buyer beware
Buccaneers at Bengals: 1 p.m. ET, Fox
Point spread: CIN -4 | Matchup quality: 38.1 (of 100)
Jenna Laine's pick: Andy Dalton and the Bengals are averaging over 26 points a game and have a multi-dimensional attack. The Bucs are missing two starters in their secondary and Pro Bowl middle linebacker Kwon Alexander, along with possibly Gerald McCoy and Vinny Curry for another week. Plus, the Bucs' offense turned the ball over four times last week against the Browns. It's hard to imagine the Bengals putting up a subpar effort after getting destroyed by the Chiefs last week. Bengals 29, Buccaneers 27
Katherine Terrell's pick: The Bengals clearly have their issues, but they're not as bad as the team that got blown out by the Chiefs on Sunday night. The Bengals have a long injury list, and the Buccaneers have a good offense, so it will probably be a high-scoring game. However, the Bengals' offense should be able to rebound at home in what the team has called a "gut-check" week. Bengals 33, Buccaneers 27
FPI win projection: CIN, 65.0 percent. This game could feature lots of offense. According to FPI, both teams rank in the top 10 in offensive efficiency and bottom 10 in defensive efficiency this season, and both teams are in the bottom 10 in opponent Total QBR.
What to watch for in fantasy: If Ronald Jones can earn double-digit touches in this contest against a soft front, he can build on last week's encouraging outing. Read more.
In case you missed it: Several factors stifling Bucs' running game ... Winston must cut down on turnovers for Bucs to thrive ... Bengals out to redefine themselves after ugly loss to Chiefs
Redskins at Giants: 1 p.m. ET, Fox
Point spread: WSH -1 | Matchup quality: 33.0 (of 100)
John Keim's pick: The Redskins have held Christian McCaffrey and Ezekiel Elliott to a combined 54 yards rushing the past two weeks. They're well-equipped to handle the Giants' run game and Saquon Barkley. The key will be stopping Barkley in the Giants' three-receiver packages, as he averages 5.13 yards per carry from this look. The Redskins take care of the ball and make teams put together long drives. Redskins 21, Giants 17
Jordan Raanan's pick: The Redskins are in the top seven in scoring defense (20.2 points per game) and total defense. It's hard to imagine the Giants' offense, which averages 19.6 points per game, does much more Sunday afternoon against Washington. They are still struggling badly to sustain consistent offense, and that's not going to change in this one. It also won't help that their defense just lost two starters. Redskins 20, Giants 16
FPI win projection: NYG, 57.9 percent. The 1-6 Giants are favored to win this game by FPI, something that won't be said very often the rest of the season. After this game the Giants are favored to win just twice by FPI.
What to watch for in fantasy: Adrian Peterson also has absorbed nine of the team's 15 rushing attempts in goal-to-go situations, meaning he's getting enough scoring opportunities to have RB1 potential this week. Read more.
In case you missed it: Redskins have formula that can work in tight NFC East ... Giants are busy compiling plenty of picks in 2019 draft
Colts at Raiders: 4:05 p.m. ET, CBS
Point spread: IND -3 | Matchup quality: 32.3 (of 100)
Mike Wells' pick: The last time the Colts were in Oakland -- Christmas Eve 2016 -- the Raiders were looked at as one of the top teams in the AFC before Derek Carr broke a leg. Things haven't been the same since for the Raiders. They're only 7-17 and have traded away linebacker Khalil Mack and receiver Amari Cooper, two key pieces to the franchise. The Colts are coming off their best performance of the season, and quarterback Andrew Luck is second in the league in touchdowns with 20. Colts 34, Raiders 16
Paul Gutierrez's pick: The shock of the Raiders' trade of Cooper to the Cowboys has yet to subside in Oakland. And with only eight of general manager Reggie McKenzie's 50 pre-Jon Gruden draft picks on the 53-man roster, players are looking over their shoulders. That's not a good recipe against a Colts team that looks reborn with a healthy Luck at quarterback. Yes, the natives in the Black Hole are restless and confused and, after Sunday, angry. Colts 27, Raiders 13
FPI win projection: OAK, 50.9 percent. The Raiders are slight favorites at home, but are one of just two teams (49ers) in the bottom 10 in both offensive (10th worst) and defensive efficiency (fourth worst) this season, according to FPI. After losing Marshawn Lynch to injury and trading Cooper, they may become the only team in the bottom five of both.
What to watch for in fantasy: Jordy Nelson already had delivered three top-25 fantasy weeks with Cooper in the picture and figures to see close to an 18-20 percent target share. Consider him a fringe WR3 against the Colts in Week 8 and beyond. Read more.
In case you missed it: Where will the Raiders play in 2019, and why isn't anyone freaking out? ... Reich is proving he's right man for Colts ... Cooper trade for first-rounder too good to pass up ... Luck is healthy again and determined to stay that way
Packers at Rams: 4:25 p.m. ET, Fox
Point spread: LAR -9.5 | Matchup quality: 69.0 (of 100)
Rob Demovsky's pick: Mike McCarthy is 9-3 coming off the bye week, including 9-2 with Aaron Rodgers as his starter. Even if Rodgers doesn't shed the brace he's worn since his Week 1 knee injury, he'll be rested with a week off. This is the kind of shootout game that Rodgers might relish given the way he's directed game-winning drives this season. He's never been a bigger underdog in his career as a starter, which would make this one of his bigger wins. Packers 41, Rams 38
Lindsey Thiry's pick: The Rams are coming off their best defensive performance yet behind four takeaways and seven sacks against the 49ers, and just in time to face a rested Rodgers and the Packers. Containing the two-time MVP will be key, and Marcus Peters pointed to the defensive backs' ability to cover their man for more than three seconds. Rams 32, Packers 28
FPI win projection: LAR, 79.8 percent. The Rams are the overwhelming favorite in this game according to FPI, a very rare occurrence for anyone against the Packers. FPI gives the Rams an 80 percent chance to win -- only once in our data set (since the start of the 2008 season) has a team been a bigger favorite over the Packers. That was the Steelers in Week 12 of last season when the Packers had Brett Hundley at QB.
What to watch for in fantasy: Widely available after weeks of battling injury and a recent bye, wide receiver Geronimo Allison is a key streaming target for this matchup with a Rams secondary that hasn't lived up to its reputation to date. Read more.
In case you missed it: Put Goff in the MVP race ... Packers happy for Shields' return ... Woods might be the Most Valuable Rams receiver ... Packers paying price now for Ted Thompson's last three drafts
49ers at Cardinals: 4:25 p.m. ET, Fox
Point spread: ARI -1 | Matchup quality: 3.5 (of 100)
Nick Wagoner's pick: The 49ers lost to this same Arizona team at home just three weeks ago in a game they dominated statistically but handed to the Cardinals with five turnovers. Turnover differential has remained the biggest problem plaguing the Niners since Jimmy Garoppolo was lost for the season. The Cardinals are coming off a bye with a new offensive coordinator, but the Niners likely won't turn it over five times again and should be able to coax Josh Rosen into a takeaway or two that will end their seven-game losing streak to Arizona. 49ers 24, Cardinals 20
Josh Weinfuss' pick: Change is coming to the Cardinals' offense and it might catch a team off guard. Byron Leftwich takes over as offensive coordinator in the wake of Mike McCoy's firing, which means more of David Johnson in the game plan. If there's one game where the Cardinals can spring an offensive explosion on somebody, it's this one because the Niners won't be able to key in on Leftwich's tendencies. Cardinals 28, Niners 17
FPI win projection: SF, 55.2 percent. This game between two 1-6 teams has a big impact on the race for the No. 1 overall pick, according to FPI. The Cardinals are the overwhelming favorite for the top pick (55 percent chance) and would see their chances climb to 71 percent with a loss. A Cardinals win would make things interesting, dropping them to 35 percent and upping the 49ers to 25 percent.
What to watch for in fantasy: Whoever gets the start for the Niners at running back -- Matt Breida or Raheem Mostert -- should find success against a Cardinals team that has allowed a RB to run for at least 90 yards and rush for a TD four times in just seven games. Read more.
In case you missed it: Cardinals' Jones knows he won't win DPOY ... Until 49ers get turnover turnaround, losses will continue ... Why Rosen will listen to new OC Leftwich
Saints at Vikings: 8:20 p.m. ET, NBC
Point spread: NO -1 | Matchup quality: 72.9 (of 100)
Mike Triplett's pick: It's hard to pick against the Saints, because even if they start slow, they finish so strong. According to ESPN Stats & Info, their 88 points in the fourth quarter/overtime this year are the most through the first six games of a season since 2002. They just came back from a 17-7 deficit at Baltimore in the fourth quarter last Sunday. Still, the Saints' five-game win streak has to end sometime. Vikings 27, Saints 24
Courtney Cronin's pick: If the Vikings want to notch their third consecutive win over the Saints, they'll have to beat the king of the fourth-quarter comeback, Drew Brees. With Xavier Rhodes' status for Sunday's game in question, the Vikings may have to rely on rookie cornerback Holton Hill to start in his place. But in the end, Kirk Cousins, Adam Thielen and defensive dominance on third down wins out. Vikings 31, Saints 28
FPI win projection: MIN, 56.0 percent. Can the Vikings' defense slow down the Saints' offense? Minnesota has the best defensive efficiency at home this season at 88.2 (on a 0-to-100 scale). Interestingly, the Saints' offensive efficiency is slightly higher on the road (80.7) than at home (74.9) this season.
What to watch for in fantasy: Thielen has been targeted on a massive 30 percent of his routes, which trails only Julio Jones (33 percent) for highest in the league. Read more.
In case you missed it: Sean Payton's new toy: A 'Thor-terback' ... Griffen practices, takes 'full responsibility' for actions ... Saints going for it with Apple trade ... Vikings' decision to keep Murray is paying off
MONDAY NIGHT FOOTBALL
Patriots at Bills: 8:15 p.m. ET, ESPN/WatchESPN
Point spread: NE -13.5 | Matchup quality: 34.2 (of 100)
Mike Reiss' pick: The Patriots haven't played a game this season without committing a turnover, and that is the Bills' best hope at pulling the upset, similar to what they did in Minnesota earlier this season. In the end, the Patriots' offensive firepower should be enough against an underwhelming Bills attack in a game that could be closer than many anticipate. Patriots 30, Bills 20
Mike Rodak's pick: The Bills' offense has scored more than 20 points in only one game this season, while the Patriots' offense has scored fewer than 20 points only once. It is going to take either an outlier performance from either of those units, or scoring from Buffalo's defense or special teams for the Bills to pull off an upset. Other than a high snap to Andrew Luck last Sunday that went for a safety, neither the Bills' defense nor special teams have scored this season. Patriots 34, Bills 17
FPI win projection: NE, 83.4 percent. The Bills have a 23.8 Total QBR as a team this season, by far the lowest in the league. Since QBR was first tracked in 2006, only five teams have posted a lower Total QBR in a season, and none since 2012.
What to watch for in fantasy: Tre'Davious White aligns on the perimeter 97 percent of the time, which is where Josh Gordon has been on 92 percent of his routes this season. Gordon should be downgraded to WR3 territory. Read more.
In case you missed it: Belichick, Pats always bear watching at NFL's trade deadline ... In Thurman Thomas' days, Bills-Patriots was very different ... How the Pats have dominated the AFC East
