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(HealthDay News) – Vitamin D3 (cholecalciferol) supplementation lowers systolic blood pressure in blacks, according to a study published in the April issue of Hypertension.
John P. Forman, MD, from Brigham and Women’s Hospital in Boston, and colleagues randomized 283 blacks (median age, 51 years) to receive 1,000, 2,000, or 4,000 international units of cholecalciferol, or placebo daily. Systolic and diastolic pressure and 25-hydroxyvitamin D were measured at baseline and at three and six months.
The researchers found that the difference in systolic pressure between baseline and three months was +1.7mmHg for those receiving placebo, -0.66mmHg for 1,000U/d, -3.4mmHg for 2,000U/d, and -4mmHg for 4,000U/d of cholecalciferol (-1.4mmHg for each additional 1,000U/d of cholecalciferol). There was a significant 0.2mmHg reduction in systolic pressure for each 1ng/mL increase in plasma 25-hydroxyvitamin D. Cholecalciferol supplementation had no effect on diastolic pressure.
“Within an unselected population of blacks, three months of oral vitamin D3 supplementation significantly, yet modestly, lowered systolic pressure,” the authors write.
Abstract
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