169  0 Kommentare Indaptus Therapeutics Previews Positive Mechanism of Action Data to be Presented at the American Association for Cancer Research Annual Meeting

NEW YORK, March 25, 2024 (GLOBE NEWSWIRE) -- Indaptus Therapeutics, Inc, (Nasdaq: INDP), a clinical stage biotechnology company dedicated to pioneering innovative cancer and viral infection treatments, announces that Dr. Michael Newman, Founder and Chief Scientific Officer of Indaptus, will present a poster at the 2024 Annual Meeting of the American Association for Cancer Research (AACR) in San Diego on Wednesday morning, April 10^th. An abstract of the data to be presented has been published online in the AACR Journal, Cancer Research. The data confirm and significantly extend the proposed mechanism of action of the Company’s proprietary platform technology of attenuated and killed, non-pathogenic bacteria containing multiple immune receptor agonists for pulsed anti-tumor immunotherapy.

Dr. Newman commented, “These new data demonstrate that our patented single agent Decoy bacteria were able to induce or activate multiple human innate and adaptive immune cell types involved in anti-tumor responses, including M1 macrophages, natural killer cells, dendritic cells, Th1 CD4, and CD8 T cells. The activity was associated with induction of human tumor cell killing by Decoy bacteria in the presence of immune cells. Potentially unacceptable toxicity from this breadth of immune activation is avoided by using systemically administered killed bacteria as a delivery vehicle. Bacteria have been shown to be cleared very quickly by immune organs, and our clinical data have demonstrated broad immune activation with clearance of the product within approximately two hours, validating our ‘pulse-prime’ hypothesis. This burst of immune system activation exhibited by Decoy has the potential to reduce the chance for toxicities associated with continuous drug exposure.”  

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Jeffrey Meckler, Indaptus’ Chief Executive Officer, added, “We are looking forward to expanding on this abstract in a poster session at the AACR conference. It confirms our hypothesis that our Decoy platform, in this case our research compound Decoy10,   activates multiple innate and adaptive immune cell types known to be critical for effective anti-tumor immune responses. The data are significant as they are highly supportive of the clinical data we have generated to date with Decoy20, which is currently in a multi-dose cohort of a Phase 1 clinical trial. It is also highly consistent with our clinical observation that single agent Decoy20 produces transient induction of dozens of cytokines and chemokines that are critical activators and effectors of both the innate and adaptive immune systems. We are looking forward to advancing our technology and demonstrating its utility for the treatment of solid tumors.