A sufferer of acromegalic gigantism, this American man measured 2.49 m (8 ft 2 in). Koehler's twin sister was 74 cm (29 in) shorter than him, a difference that set a world record. The Tel Aviv ...

Bragg-peak proton hypophysectomy was used in 22 acromegalic patients. Of 14 followed for two to 36 months, size of hands, feet or face decreased in nine. Variable improvement took place in ...

In patients with growth-hormone-secreting pituitary macroadenomas, acromegalic symptoms might resolve after trans-sphenoidal surgery, but additional drug therapy is needed in about 50% of cases.

These mechanisms suggest that whereas the liver becomes relatively resistant to growth hormone during somatostatin analog treatment, acromegalic symptoms still persist in other parts of the body.

Figure 2. Hand of a patient with acromegaly compared to a normal hand Adenomas developing from growth hormone-secreting cells cause acromegaly or acromegalic gigantism (if they start in childhood).

The pituitary tumour types occurring in these families are most commonly growth hormone-secreting adenomas (causing acromegaly or acromegalic gigantism), prolactin-secreting adenomas (prolactinomas) ...