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Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
1 Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. 2 Department of ...
Facing Plan S, publishers may set papers free
Plan S, the funder-backed scheme to require free online access to scientific literature, aims to shake up the subscription ...
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
1 Max Planck Institute for Brain Research, Frankfurt, Germany. 2 Department of Anatomy, School of Biomedical Sciences and the ...
European Commission kills billion-euro flagship concept
When Martin Lohse, scientific director of the Max Delbrück Center for Molecular Medicine here, welcomed participants to the ...
Hierarchical reasoning by neural circuits in the frontal cortex
Primates can compute and integrate low-level decisions to make strategic adjustments to higher-level decisions. The neural ...
Interferometry spots an exoplanet
The GRAVITY Collaboration used the Very Large Telescope, located in the Atacama Desert of northern Chile, to observe the star ...
Sydney Brenner (1927–2019)
Sydney Brenner, an icon of science, died on 5 April at age 92. Sydney helped decipher the genetic code, he pioneered the use ...
Putting sugars under strain
The conformation of a sugar molecule determines how it reacts to form chains. Two studies in this issue show how adding ...
Machine learning improves hearing aids
A key challenge in improving assistive hearing devices is isolating and separating different voices in noisy or crowded settings. This task is especially difficult without prior exposure to the voices ...
Curbing the costs of chemical manufacturing
The search for new drug candidates has led pharmaceutical investigators to explore molecular structures of increasing complexity. This requirement is the result of the growing recognition that ...
Spatiotemporal light control with active metasurfaces
Optical metasurfaces have opened an entirely new field in the quest to manipulate light. Optical metasurfaces can locally ...
Senolytic therapies for healthy longevity
The estimated “natural” life span of humans is ∼30 years, but improvements in working conditions, housing, sanitation, and ...