Injuries to epithelia that breach the basement membrane allow epithelial cells to come into contact with the underlying stroma. Epithelial-stromal interactions are critical for matrix remodeling and ...
1 Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham School of Medicine, ...
1 Leap Therapeutics, Cambridge, MA 02141, USA. 2 Department of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford ...
1 Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan. 2 Laboratory of Clinical Analytical Sciences, ...
VCAM1-dependent inflammation in aged brain endothelial cells suppresses neurogenesis and cognitive performance. Aging results in neuroinflammation induced by the activation of microglia, the resident ...
It is an unfortunate aspect of aging that memory tends to decline. Butler et al. identified one way by which that happens. ...
1 Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan. 2 Innovative Technology Planning ...
Studies provide critical insight into the roles and regulation of NMDA receptors in learning and memory. In the Archives, Yu et al. found that the acid-sensing channel ASIC1a promoted the synaptic ...
TAM family kinases promote necroptosis by stimulating the phosphorylation and oligomerization of the pseudokinase MLKL. Necroptosis is a necrotic form of cell death that depends on signaling ...
1 CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. 2 Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. 3 Institute for ...
A previously undescribed enzyme promotes lipidation of a ubiquitin ligase that regulates PI3K and Ca 2+ signaling. The process of modifying target proteins with lipids, which is known as prenylation, ...
1 Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA. 2 Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of ...