Copilot
Your everyday AI companion
About 6,570,000 results
  1. See more
    See more
    See all on Wikipedia
    See more

    Variant of uncertain significance - Wikipedia

    A variant of uncertain (or unknown) significance (VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known. Two related terms are "gene of uncertain significance" (GUS), which refers to a gene that has been โ€ฆ See more

    In 2001, an initial draft of the human genome was published by the International Human Genome Sequencing Consortium. Withโ€ฆ See more

    The number of VUS reports makes it impossible to mention all such reports. To give a flavor for some applications in one field, it is perhaps of most interest to focus on breast cancer. โ€ฆ See more

    Classification image

    Less than 5% of the human genome encodes proteins, and the rest is associated with non-coding RNA molecules, regulatoryโ€ฆ See more

    โ€ข Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, et al. (January 2017). "Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: Aโ€ฆ See more

    Wikipedia text under CC-BY-SA license
    Feedback
  2. What to do if your genetic test finds a variant of โ€ฆ

    WebSeptember 29, 2021. Genetic testing found a variant of uncertain significance. Now what? BY Ronda Wendler. When you agree to genetic testing, you expect a yes or no answer: yes, you have an abnormal โ€ฆ

  3. People also ask
    If the variantโ€™s Functional Significance is Unknown and there is no known effect of the variant on therapeutic sensitivity or resistance, the variant is classified as either Unknown or Potentially for its Variant Actionability.
    A variant of uncertain ( or unknown) significance ( VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known.
    en.wikipedia.org/wiki/Variant_of_uncertain_significance
    When analysis of a patientโ€™s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS). In many cases, these variants are so rare in the population that little information is available about them.
    www.genome.gov/genetics-glossary/Variant-of-Uncertain โ€ฆ
    Such reports are becoming more frequent in general practice, and neurologists are often left to puzzle over the relevance of these โ€œvariants of unknown significance,โ€ as such genetic changes are often described, and how to communicate this information to the patients and their families.
    www.ncbi.nlm.nih.gov/pmc/articles/PMC3587691/
  4. The importance of variants of unknown significance (VUS) in BRCA ...

  5. Variant of Uncertain Significance (VUS) - National โ€ฆ

    Web6 days ago · There is so much about the genome we don't know. Sometimes it seems we're just scratching the surface. In fact, the great majority of new variants that pop up in examining an individual person's โ€ฆ

  6. Actionability classification of variants of unknown significance ...

  7. Whatโ€™s a โ€œVariant of Uncertain Significance?โ€ A VUS?

    WebMay 3, 2018 · - DNA Science. Whatโ€™s a โ€œVariant of Uncertain Significance?โ€ A VUS? May 3, 2018 Ricki Lewis, PhD Uncategorized. Seven words someone taking a genetic test doesnโ€™t want to hear: โ€œYou โ€ฆ

  8. Selecting variants of unknown significance through network

  9. Analysis of BRCA1/2 variants of unknown significance in the

  10. Understanding genetic variants of uncertain significance - PMC

  11. INTERPRETATION OF GENETIC TESTING: VARIANTS OF โ€ฆ