Ethionamide. EthionamideSulfoxide is an active metabolite. EthionamideSulfoxide is inter-convertible to Ethionamide in vivo. Regards Dr Ashish Mungantiwar
[Comparative in vitro investigations on the tuberculostatic effectiveness of ethionamide and its sulfoxide] Beitr Klin Erforsch Tuberk Lungenkr. 1965; 132():311-4.
Ethionamide-sulfoxide is the major metabolite; it has been reported to have antibacterial activity. The plasma half-life of ethionamide is approximately 2-3 hours.
Metabolized to the active metabolite sulfoxide, and several inactive metabolites. ... with continued ethionamide monotherapy, but did not occur when mice received ethionamide in ...
Synthetic chemical conversion of the ethionamide thioamide group to a sulfoxide lowers the drug MIC for M. Smegmatis and M. Aberculosis. We have isolated a gene containing a ...
... is extensively metabolized, probably in the liver, to ethionamide sulphoxide, 2-ethylisonicotinic acid and 2-ethylisonicotinamide. The sulfoxide is the ...
"Simultaneous determination of Ethionamide and it's active metabolite EthionamideSulfoxide in Human Plasma and study of its pharmacokinetics in healthy male volunteer by High ...
The clinical significance of plasma, AC, and ELF ethionamide concentrations in the treatment of tuberculosis is uncertain and requires further investigation. Although the sulfoxide ...
Ethionamide: Chemically related to INH, converted via oxidation to ethionamidesulfoxide, blocks the synthesis of mycolic acids [4,5]. Inhibits most tubercle bacilli at concentrations ...