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  1. Insights from transgenic mouse models of PyMT-induced breast …

  2. Insights from transgenic mouse models of PyMT-induced breast …

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    Therapeutics with clinical potential tested in PyMT. Blocks the Programmed death ligand (PDL1) that is commonly expressed by tumor cells to inhibit T cell activity. Increased CD8+ T cell activity, decreased tumor burden. Adenovirus expressing the cytokine IL12 and the co-stimulatory molecule B7-1 that activates T cells.
    Despite not being a human oncogene, PyMT mimics the signaling of receptor tyrosine kinases which are commonly activated in many human malignancies including breast cancer. Fig. 1: Notable advances in GEMMs of breast cancer. The unenveloped double stranded murine polyomavirus was discovered in 1953.
    Created with Biorender.com . Despite the focus on the hematogenous route of metastasis, the PyMT model does metastasize, albeit to a low extent, to the lymph node, a common metastatic site in human breast cancer [ 103 ].
    Thus, PyMT models are clinically relevant mouse models used for pre-clinical testing of various therapeutic methods to determine doses, safety, and efficacy. Therapeutics with clinical potential tested in PyMT. Blocks the Programmed death ligand (PDL1) that is commonly expressed by tumor cells to inhibit T cell activity.
  4. Mouse models of breast cancer metastasis - Wikipedia

  5. Mouse models of breast cancer metastasis - PMC - National …

  6. PyMT – a transplantable murine model of breast cancer

  7. Transgenic Mouse Models of Breast Cancer - PMC - National …

  8. Spatially and functionally distinct subclasses of breast cancer ...

  9. New mouse genetic model of breast cancer from - Nature

  10. Comparing syngeneic and autochthonous models of breast cancer …