Don't Give Up on us is a romantic comedy from the Philippines about a young woman who falls in love while on a quest to find her errant best friend. Abby's best friend, Sabina, is engaged to Abby's brother, but Sabina disappears suddenly a short time before the wedding is scheduled to happen. Abby sets out to find Sabina and save the day, but along the way she meets Vince, a young folk singer whose voice she's heard on the mysterious tape left behind by Sabina. The pair continue the search, but their budding love proves to be something of a distraction.