Aquone is an unincorporated community in Macon County, North Carolina, United States. Aquone is located near the Nantahala River, 29 miles …Aquone is an unincorporated community in Macon County, North Carolina, United States. Aquone is located near the Nantahala River, 29 miles west of Franklin. Aquone had a post office until it closed on January 12, 1996. The community's name is derived from the Cherokee word egwanul'ti, meaning "by the river".