Brandenburg is a home rule-class city on the Ohio River in Meade County, Kentucky, in the United States. The city is 46 miles southwest of Louisville. It is the seat of its county. The population was 2…Brandenburg is a home rule-class city on the Ohio River in Meade County, Kentucky, in the United States. The city is 46 miles southwest of Louisville. It is the seat of its county. The population was 2,643 at the 2010 census.