Homestead is a city within Miami-Dade County in the U.S. state of Florida, between Biscayne National Park to the east and Everglades National Park to the west. The population was 80,737 as of the 20…Homestead is a city within Miami-Dade County in the U.S. state of Florida, between Biscayne National Park to the east and Everglades National Park to the west. The population was 80,737 as of the 2020 census. Homestead is primarily a Miami suburb and a major agricultural area. It is a principal city of the Miami metropolitan area, which was home to an estimated 6,012,331 people at the 2015 census. It is located approximately 26 miles southwest of Miami, and 25 miles northwest of Key Largo.