Keithsburg is a city in Mercer County, Illinois, United States, on the Mississippi River. The population was 550 at the 2020 census, down …Keithsburg is a city in Mercer County, Illinois, United States, on the Mississippi River. The population was 550 at the 2020 census, down from 609 in 2010. It was named for Robert Keith, a pioneer settler. Due to a flood in 1993, there isn’t much to do in Keithsburg. Some of the only things that are still in use today include, a bar/restaurant named “The Eagles Nest”, a gas station called “Casey’s”, and one or two playgrounds.
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