Saint Joseph is a city in Lawrence County, Tennessee, United States. The population was 782 at the 2010 census, down from 829 in 2000. The …Saint Joseph is a city in Lawrence County, Tennessee, United States. The population was 782 at the 2010 census, down from 829 in 2000. The St. Joseph area was settled by German Catholic immigrants in the early 1870s. These settlers established St. Joseph Catholic Church, which is still home to a Catholic parish. By the late 1880s, St. Joseph had about twenty-five houses, a school, and a store.