The Middle Fork Koyukuk River is a 62-mile tributary of the Koyukuk River in the U.S. state of Alaska. Formed by the confluence of the Bettles and Dietrich rivers near Wiseman on the southern flank of the Brooks Range, the Middle Fork flows generally southwest to its confluence with the North Fork Koyukuk River, with which it forms the main stem of the Koyukuk.
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