New Brunswick is a city in and the seat of government of Middlesex County, in the U.S. state of New Jersey. The city is the home of Rutgers University. The city is both a regional commercial hub for c…New Brunswick is a city in and the seat of government of Middlesex County, in the U.S. state of New Jersey. The city is the home of Rutgers University. The city is both a regional commercial hub for central New Jersey and a prominent and growing commuter town for residents commuting to New York City within the New York metropolitan area. New Brunswick is on the Northeast Corridor rail line, 27 miles southwest of Manhattan. The city is located on the southern banks of the Raritan River in the Raritan Valley region.