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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

Smartphone app and health coach combo improves surgical outcomes

Coupling a smart phone app with a real-life health coach appears to be key to helping patients adhere to pre-surgical preparation and post-surgical recovery guidance and improving surgical outcomes, according to new findings led by UPMC and University of Pittsburgh School of Medicine physician-scientists.

4 Apr 2024

Stem cell therapy safe and potentially beneficial for spinal cord injury patients

A Mayo Clinic study shows stem cells derived from patients' own fat are safe and may improve sensation and movement after traumatic spinal cord injuries.

1 Apr 2024

Simple pre-surgical protocol can help prevent dangerous post-surgical infections

A new study published today in the American Journal of Infection Control (AJIC) demonstrates the use of a simple pre-surgical infection prevention protocol to prevent dangerous post-surgical infections.

28 Mar 2024

New battery-free implant allows users to monitor their bladder fullness in real time

Should you run to the bathroom now? Or can you hold it until you get home? A new implant and associated smartphone app may someday remove the guess work from the equation.

26 Mar 2024

Study highlights global fertility decline and its implications for the future

The world is approaching a low-fertility future. Although by 2100 more than 97% of countries and territories will have fertility rates below what is necessary to sustain population size over time, comparatively high fertility rates in numerous low-income countries, predominantly in western and eastern sub-Saharan Africa, will continue to drive population increases in these locations throughout the century.

21 Mar 2024

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health.

20 Mar 2024

Risk factors for serious inflammatory conditions in IBD patients identified

Investigators at Cedars-Sinai have identified risk factors that make inflammatory bowel disease (IBD) patients susceptible to developing serious conditions in other parts of their bodies.

20 Mar 2024

The effects of high maternal folate intake on the health outcomes of offspring

Researchers summarized what is known about the effects of excessive folic acid (FA) supplementation for mothers on children.

8 Mar 2024

Female ginseng compound holds promise as osteoporosis treatment

With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis.

21 Feb 2024

Yoga may benefit individuals with back pain

New research published in the Journal of Orthopaedic Research suggests that the physical postures, breathing exercises, and mindfulness practices of yoga may benefit individuals with back pain.

21 Feb 2024

Residual paresthesia impacts patient satisfaction post-surgery for cervical spondylotic myelopathy

Pins and needles, sudden cold, burning, itching, numbness in the limbs — these are symptoms of paresthesia in cervical spondylotic myelopathy caused by compression of the spinal cord pathway in the cervical spine due to aging or other factors.

20 Feb 2024

Study provides evidence that antidepressant use in pregnancy affects child's brain development

A new study explored synapse maturation in the PFC of mice when exposed to 5-HT, shedding light on the link between the chemical and future behavioral changes.

19 Feb 2024

Single-dose genetic medicine halts the progression of ALS and frontotemporal dementia in mice

Neuroscientists at Macquarie University in Australia have developed a single-dose genetic medicine that has been proven to halt the progression of both ALS and frontotemporal dementia (FTD) in mice – and may even offer the potential to reverse some of the effects of the fatal diseases.

19 Feb 2024

Spine News and Research

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Smartphone app and health coach combo improves surgical outcomes

Stem cell therapy safe and potentially beneficial for spinal cord injury patients

Simple pre-surgical protocol can help prevent dangerous post-surgical infections

New battery-free implant allows users to monitor their bladder fullness in real time

Study highlights global fertility decline and its implications for the future

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

Risk factors for serious inflammatory conditions in IBD patients identified

The effects of high maternal folate intake on the health outcomes of offspring

Female ginseng compound holds promise as osteoporosis treatment

Yoga may benefit individuals with back pain

Residual paresthesia impacts patient satisfaction post-surgery for cervical spondylotic myelopathy

Study provides evidence that antidepressant use in pregnancy affects child's brain development

Single-dose genetic medicine halts the progression of ALS and frontotemporal dementia in mice

Insights into how AI and wearable technologies are impacting the future of healthcare

Study provides insight into potential mechanisms underlying diabetes-related disc tissue damage

Low back pain? There’s good and bad news

New study reveals optimal drug sequencing for postmenopausal osteoporosis treatment

Beyond the scale: B.A.S.I.C.S. checklist takes a holistic view of health

Is a gluten-free diet always the healthier choice for women?

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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