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Emerging role of exosomes as promising diagnostic tool for cancer

Cancer Gene Therapy volume 27, pages 395–398 (2020)Cite this article

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Abstract

The incidence of cancer is experiencing a steep rise in recent times. A survey report produced by GLOBOCAN 2018 estimates about 18.1 million new cases of cancer across 20 regions of the world. The bewildering number of people afflicted with cancer demands rapid diagnosis and treatment strategy. The current methods used for diagnosis of cancer are expensive, invasive, and time consuming. Hence, a new diagnostic panel has to be laid down to make the process less invasive, cost-effective, and rapid. A venture into identifying potential diagnostic targets introduced exosomes to the scientific community. A plethora of roles being packed into these biological cargoes makes them attractive targets for both therapeutic and diagnostic applications. Exosomes are membrane-bound extracellular vesicles packed with DNA, RNA, and proteins. Their presence in a wide array of body fluids such as breast milk, blood plasma, saliva, urine, serum, and cerebrospinal fluid makes them an excellent source of potential biomarkers. These nano-scale structures are capable of crossing hypoxic regions, systemic circulation and the territories of blood vessel barriers. In line with the above facts, the present review focuses on the therapeutic and diagnostic applications of exosomes in cancer.

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Authors and Affiliations

  1. Biomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 600077, India

    Vijayashree Priyadharsini Jayaseelan

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  1. Vijayashree Priyadharsini Jayaseelan
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Correspondence to Vijayashree Priyadharsini Jayaseelan.

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Jayaseelan, V.P. Emerging role of exosomes as promising diagnostic tool for cancer. Cancer Gene Ther 27, 395–398 (2020). https://doi.org/10.1038/s41417-019-0136-4

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