Limiting Adenosine In The Brain Expands Auditory Learning Until Adulthood

The ability to learn a language and know the sound of music has been preserved by limiting the supply or the function of the neuromodulator adenosine in a brain structure called the auditory thalamus, reveal researchers.

St. Jude //Children’s Research Hospital scientists have evidence from mice that restricting a key chemical messenger in the brain helps extend efficient auditory learning much later in life. The study appears in the Journal Science.

Adenosine Therapy Prevents Epilepsy Progression
Epilepsy is characterized by recurrent seizures that is present in many different ways. Sometimes, epileptic patients exhibit a progressive increase in both frequency and severity of seizures.

‘Adenosine inhibition not only reduced the efficiency of auditory learning, but also reduced brain plasticity.’

Tweet it Now

"By disrupting adenosine signaling in the auditory thalamus, we have extended the window for auditory learning for the longest period yet reported, well into adulthood and far beyond the usual critical period in mice," said corresponding author Stanislav Zakharenko, M.D., Ph.D., a member of the St. Jude Department of Developmental Neurobiology.

"These results offer a promising strategy to extend the same window in humans to acquire language or musical ability by restoring plasticity in critical regions of the brain, possibly by developing drugs that selectively block adenosine activity."

The auditory thalamus is the brain’s relay station where sound is collected and sent to the auditory cortex for processing.

A2b-type Adenosine Receptor Plays Vital Role in Obesity and Diabetes Regulation
American researchers have found that A2b-type adenosine receptor, A2bAR, is vital in regulation of high fat, high cholesterol diet-induced symptoms of type 2 diabetes.

The auditory thalamus and cortex rely on the neurotransmitter glutamate to communicate. Adenosine was known to reduce glutamate levels by inhibiting this neurotransmitter’s release. This study also linked adenosine inhibition to reduced brain plasticity and the end of efficient auditory learning.

Researchers used a variety of methods to demonstrate that reducing adenosine or blocking the A1 adenosine receptor that is essential to the chemical messenger’s function changed how adult mice responded to sound.

New Study Sheds Light on How Cancer Cells Cheat Death
Cancer cells don't die when they're supposed to, they escape programmed cell death, called apoptosis, and multiply uncontrollably.

Much as young children pick up language simply by hearing it spoken, researchers showed that when adenosine was reduced or the A1 receptor blocked in the auditory thalamus, adult mice passively exposed to a tone responded to the same tone stronger when it was played weeks or months later. These adult mice also gained an ability to distinguish between very close tones (or tones with similar frequencies). Mice usually lack this "perfect pitch" ability.

Researchers also showed that the experimental mice retained the improved tone discrimination for weeks.

Discovery of Gene Variation Linked to Bipolar Disorder Leads to Development of New Therapies
The genetic variation was found in the cAMP messenger pathway of a gene known as PDE10A. This variation was found to increase the susceptibility of bipolar disorder.

"Taken together, the results demonstrated that the window for effective auditory learning re-opened in the mice and that they retained the information," Zakharenko said.

Among the strategies researchers used to inhibit adenosine activity was the experimental compound FR194921, which selectively blocks the A1 receptor. If paired with sound exposure, the compound rejuvenated auditory learning in adult mice.

"That suggests it might be possible to extend the window in humans by targeting the A1 receptor for drug development," Zakharenko said.

Zakharenko and his colleagues also linked the age-related decline in ease of auditory learning to an age-related increase in an enzyme (ecto-5’-nucleotidase) involved in adenosine production in the auditory thalamus.

Researchers reported that mature mice had higher levels than newborn mice of the enzyme and adenosine in the auditory thalamus. Deletion of this enzyme returned the adenosine level in adult mice to the level of newborn mice. Therefore, researchers are currently looking for compounds that target ecto-5’-nucleotidase as an alternative approach for extending the window of auditory learning.

Source-Eurekalert