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A potent targeted cancer nanotherapeutic

Nature Biomedical Engineering volume 3, pages 248–250 (2019)Cite this article

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An antibody-modified nanoparticle encapsulating a pH-sensitive taxane prodrug, and targeting an overexpressed receptor in tumours, improves the tolerability and anticancer efficacy of the active drug in multiple animal models.

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Fig. 1: Chemical structure of the antibody-targeted nanotherapeutic MM-310.
Fig. 2: Therapeutic efficacy of MM-310.

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Authors and Affiliations

  1. Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia

    Ernesto Moles & Maria Kavallaris

  2. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Australian Centre for Nanomedicine, University of New South Wales, Sydney, New South Wales, Australia

    Ernesto Moles & Maria Kavallaris

  3. School of Women’s and Children’s Health, University of New South Wales, Sydney, New South Wales, Australia

    Ernesto Moles & Maria Kavallaris

Authors
  1. Ernesto Moles
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  2. Maria Kavallaris
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Correspondence to Maria Kavallaris.

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Moles, E., Kavallaris, M. A potent targeted cancer nanotherapeutic. Nat Biomed Eng 3, 248–250 (2019). https://doi.org/10.1038/s41551-019-0390-7

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