New England Patriots at Buffalo Bills: Predictions, picks and odds for NFL Week 18 matchup

USA TODAY

Bill Belichick's New England Patriots (8-8) face a win-and-in situation when they travel to Buffalo for a battle against Josh Allen's Bills (12-4).

Even with a struggling offense, Patriots QB Mac Jones and Co. control their own destiny and can make the postseason with a Week 18 victory. But the Bills aren't likely to lay down against their longtime AFC East rivals. Which team comes out with a win in the regular-season finale? The game is expected to kick off Sunday at 1 p.m. ET from Highmark Stadium.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Patriots vs. Bills Week 18 game:

Patriots at Bills odds, moneyline and over/under

Spread: Bills (-7.5)
Moneyline: Bills (-340); Patriots (+280)
Over/under: 43
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NFL Week 18 odds, predictions and picks

Lorenzo Reyes: Bills 27, Patriots 17

This is a really complicated situation. Buffalo’s players will have heavy hearts but will also surely want to do right by their loved teammate. The Patriots need to secure a victory to fend off a potential Dolphins charge for the last wild-card spot in the AFC. Damar Hamlin, however, should continue to be the focus; perhaps the best way to do that would be to donate to Hamlin’s toy drive fundraiser instead.

Safid Deen: Bills 31, Patriots 24

With heavy hearts for safety Damar Hamlin, the Bills will get back on track at home and take care of their AFC East rival New England this week. The loss will bounce the Patriots from the playoffs.

Richard Morin: Patriots 24, Bills 23

This is a challenging one to think about. Given Damar Hamlin's condition, it's still an important game with ramifications for both the Patriots and Bills, but it's tough to see how this one will play out given so many factors.

Jarrett Bell: Bills 24, Patriots 20

Nate Davis: Bills 27, Patriots 16

Tyler Dragon: Bills 26, Patriots 20

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