A new prostate cancer test with a 94% accuracy rate could help identify more men with the disease.
Experts said the standard PSA blood test can result in unnecessary biopsies and “false reassurance in men with cancer”.
But a chromosomal PSE test was said to significantly improve detection.
A team from Imperial College and the University of East Anglia advised combining them.
A pilot study of 147 patients evaluated the new test, called PSE, and found it significantly improved detection of the disease.
All the men in the study had prostate cancer and the test was 94% accurate.
The next stage of research will be to use the test on a group of men where the cancer status is unknown.
Professor Dmitry Pshezhetskiy, from UEA's Norwich Medical School, said: "Prostate cancer is the most common cancer in men and kills one man every 45 minutes in the UK.
"There is currently no single test for prostate cancer, but PSA blood tests are among the most used, alongside physical examinations, MRI scans and biopsies.
"However, PSA blood tests are not routinely used to screen for prostate cancer, as results can be unreliable.
"Only about a quarter of people who have a prostate biopsy due to an elevated PSA level are found to have prostate cancer.
"There has therefore been a drive to create a new blood test with greater accuracy.
"When tested in the context of screening a population at risk, the PSE test yields a rapid and minimally invasive prostate cancer diagnosis with impressive performance. This suggests a real benefit for both diagnostic and screening purposes."
Dr Jon Burrows, chief executive at Oxford Biodynamics, said: "There is a clear need in everyday clinical practice for a highly accurate blood test that can screen men for prostate cancer and accurately identify those at risk, while sparing those who up to now would be subject to unnecessary, expensive and invasive procedures."
Publishing their findings in the journal Cancers, the team said the PSA test currently widely used in the NHS does not have sufficient accuracy, resulting in numerous unnecessary prostate biopsies in men with no cancer and "false reassurance in some men with cancer".
The researchers developed a new chromosomal test which can pick up signals of cancer and combined it with the regular PSA test.