An imbalance of the body’s oxygen producing free radicals and its antioxidant cells could be the reason why gum disease and chronic kidney disease affect each other, a new study by an Indian-origin medic in the UK has found. Periodontitis or gum disease is a common, inflammatory disease which causes bleeding gums, wobbly or drifting teeth and can eventually result in tooth loss.
Previous studies have shown a link between the severe oral inflammation caused by gum disease and chronic kidney disease (CKD), which demonstrated that those with worse inflammation of the gums have worse kidney function. In the latest study led by Dr Praveen Sharma at the University of Birmingham, over 700 patients with chronic kidney disease were examined using detailed oral and full-body examinations including blood samples. The aim was to test the hypothesis that periodontal inflammation and kidney function affect each other and to establish the underlying mechanism that may facilitate this.
This is the first paper to quantify the causal effect of periodontitis on kidney function and vice-versa as well as the first to elucidate the pathways involved, said Sharma, from the Periodontal Research Group at the university’s School of Dentistry. It showed that even a modest reduction in gum inflammation can benefit renal function. Given the relative ease of achieving a 10 per cent reduction in gum inflammation, through simple measures like correct brushing techniques and cleaning between the teeth, these results are very interesting, he said.
Previous research has also shown that patients with CKD and periodontitis experience a drop in survival rates, similar in magnitude to if they had diabetes instead of gum inflammation, suggesting that gum inflammation may casually affect kidney function. Results from the new study showed that just a 10 per cent increase in gum inflammation reduces kidney function by 3 per cent. In this group of patients, a 3 per cent worsening in kidney function would translate to an increase in the risk of kidney failure over a five-year period from 32-34 per cent.
Results also showed that a 10 per cent reduction in kidney function increases periodontal inflammation by 25 per cent. In contrast to current beliefs that inflammation is the link between periodontitis and other systemic diseases, researchers found for the first time, that in this group of patients, the effect was caused by a biological process called oxidative stress or, an imbalance between reactive oxygen species and the body’s antioxidant capacity which damages tissues on a cellular level.
We hope that this research paves the way for further studies to see if improvements in kidney function, following periodontal care, translate to longer, healthier life for patients with chronic kidney disease. We would also hope that the hypothesis we have identified could be tested in other groups, said Dr Sharma. His paper, Oxidative stress links periodontal inflammation and renal function, has been published in the Journal of Clinical Periodontology’.
The research was led by the Periodontal Research Group at the University of Birmingham’s School of Dentistry, in collaboration with University Hospital Birmingham, Aston University, Boston University and Swansea University and funding from the Oral and Dental Research Trust and Kidney Research UK lending support.
