This story is from November 12, 2016

Found: Way to create stronger heart cells

The new discovery advances efforts to find effective treatments for heart failure.
Found: Way to create stronger heart cells
Found: Way to create stronger heart cells (Getty Images)
Scientists, including one of Indian origin, have identified two chemicals which can improve speed, quantity and quality of direct cardiac reprogramming, bringing the technology to regenerate damaged hearts one step closer. The new discovery advances efforts to find effective treatments for heart failure.
Scientists at the Gladstone Institutes in the US are exploring cellular reprogramming in the heart as a way to regenerate muscle cells in the hopes of curing heart failure.
It takes only three transcription factors -proteins that turn genes on or off in a cell -to reprogramme connective tissue cells into heart muscle cells in a mouse. After a heart attack, connective tissue forms scar tissue at the site of the injury , contributing to heart failure.
The three factors, Gata4, Mef2c, and Tbx5 (GMT), work together to turn heart genes on in these cells and turn other genes off, effectively regenerating a damaged heart with its own cells. However, the method is not foolproof.
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