Future Perspective
We have demonstrated that the Au–lysozyme NCs can target notorious pathogenic bacteria, including PDRAB, VRE, E. coli and S. aureus. The cell growth of these bacteria can be effectively inhibited, implying the possibility of using this approach for antimicrobial nanotherapeutics. In addition, no apparent cell toxicity of the Au–lysozyme NCs was observed based on our examination in vitro. On the basis of the results presented in this work, we are quite optimistic for its future application to medical treatment in the real world. Nevertheless, more antibiotic-resistant bacterial strains should be investigated, and in vivo examination is required to further prove this possibility in practice.
Financial & competing interests disclosure
The authors thank the National Science Council (NSC) of Taiwan for financial support of this work. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Nanomedicine. 2010;5(5):755-764. © 2010 Future Medicine Ltd.
Cite this: Functional Gold Nanoclusters as Antimicrobial Agents for Antibiotic-resistant Bacteria - Medscape - Jul 01, 2010.
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