Heidi Flori, MD; Mary K. Dahmer, PhD; Anil Sapru, MD, MAS; Michael W. Quasney, MD, PhD
DisclosuresPediatr Crit Care Med. 2015;16(5):s41-s50.
Organ Failure | Died (n = 41) | Survived (n = 76) | OR | 95% CI | p |
---|---|---|---|---|---|
Cardiac | 34 (82.9) | 39 (51.3) | 4.61 | 1.82–11.67 | 0.001 |
Neurologic | 20 (48.8) | 13 (17.1) | 4.61 | 1.96–10.86 | < 0.001 |
Hematologic | 28 (68.3) | 20 (26.3) | 6.03 | 2.62–13.87 | < 0.001 |
Hepatic | 18 (43.9) | 13 (17.1) | 3.79 | 1.61–8.95 | 0.002 |
Renal | 20 (48.8) | 6 (7.9) | 11.11 | 3.95–31.26 | < 0.001 |
Renal replacement | 13 (31.7) | 2 (2.6) | 17.18 | 3.64–81.01 | < 0.001 |
Multiple organ failure | 24 (58.5) | 11 (14.5) | 8.34 | 3.42–20.34 | < 0.001 |
OR = odds ratio.
Reproduced with permission from Erickson et al (5). Copyright 2007
Biomarker | Pathophysiological Role in Lung Injury | Reference |
---|---|---|
von Willebrand factor | Activation and injury of systemic and pulmonary endothelial cells | 69 |
Soluble intercellular adhesion molecule-1 | Adherence of neutrophils to pulmonary endothelial cells | 69, 70 |
Endothelin-1 | Endothelial cell injury | 77 |
PAI-1 | Impaired fibrinolysis with elevated PAI-1 contributing to deposition of fibrin in injured alveoli | 71 |
B-type natriuretic peptide | Impaired cardiac function secondary to poor lung compliance | 78 |
PAI = plasminogen activation inhibitor..
Heidi Flori, MD1, Mary K. Dahmer, PhD2, Anil Sapru, MD, MAS3 and Michael W. Quasney, MD, PhD4
1Division of Pediatric Critical Care, Department of Medicine, Children's Hospital & Research Center Oakland, Oakland, CA.
2Division of Pediatric Critical Care, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
3Division of Critical Care, Department of Pediatrics, University of California San Francisco, San Francisco, CA.
4Division of Pediatric Critical Care, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Organizing Committee: Philippe Jouvet, University of Montreal, Canada; Neal J. Thomas, Pennsylvania State University; Douglas F. Willson, Medical College of Virginia
Section 1, Definition, incidence, and epidemiology: Simon Erickson, Princess Margaret Hospital for Children, Australia; Robinder Khemani, University of Southern California; Lincoln Smith, University of Washington; Jerry Zimmerman, University of Washington
Section 2, Pathophysiology, comorbidities, and severity: Mary Dahmer, University of Michigan; Heidi Flori, Children's Hospital & Research Center Oakland; Michael Quasney, University of Michigan; Anil Sapru, University of California San Francisco
Section 3, Ventilatory support: Ira M. Cheifetz, Duke University; Peter C. Rimensberger, University Hospital of Geneva, Switzerland
Section 4, Pulmonary-specific ancillary treatment: Martin Kneyber, University Medical Center Groningen, The Netherlands; Robert F. Tamburro, Pennsylvania State University
Section 5, Nonpulmonary treatment: Martha A. Q. Curley, University of Pennsylvania; Vinay Nadkarni, University of Pennsylvania; Stacey Valentine, Harvard University
Section 6, Monitoring: Guillaume Emeriaud, University of Montreal, Canada; Christopher Newth, University of Southern California
Section 7, Noninvasive support and ventilation: Christopher L. Carroll, University of Connecticut; Sandrine Essouri, Université Pierre et Marie Curie, France
Section 8, Extracorporeal support: Heidi Dalton, University of Arizona; Duncan Macrae, Royal Brompton Hospital, United Kingdom
Section 9, Morbidity and long-term outcomes: Yolanda Lopez, Cruces University Hospital, Spain; Michael Quasney, University of Michigan; Miriam Santschi, Université de Sherbrooke, Canada; R. Scott Watson, University of Pittsburgh
Literature Search Methodology: Melania Bembea, Johns Hopkins University
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