Antimicrobial agents and chemotherapy

(ISSN: 0066-4804, 1098-6596)

Table of Contents

From Antimicrobial agents and chemotherapy

2023 -

  • Individual meropenem epithelial lining fluid and plasma PK/PD target attainment. 
  • Cytochrome P450 2D6 profiles and anti-relapse efficacy of tafenoquine against Plasmodium vivax in Australian Defence Force personnel. 
  • Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis: a phase 1 open-label population pharmacokinetic study. 
  • Safety, tolerability, and pharmacokinetics of ibrexafungerp in healthy Chinese subjects: a randomized, double-blind, placebo-controlled phase 1 trial. 
  • Plasmid genomic epidemiology of blaKPC carbapenemase-producing Enterobacterales in Canada, 2010-2021. 
  • Unraveling the mechanism of ceftaroline-induced allosteric regulation in penicillin-binding protein 2a: insights for novel antibiotic development against methicillin-resistant Staphylococcus aureus. 
  • In vitro and in vivo activity of cefiderocol against Achromobacter spp. and Burkholderia cepacia complex, including carbapenem-non-susceptible isolates. 
  • Optimizing dosing of the cycloserine pro-drug terizidone in children with rifampicin-resistant tuberculosis. 
  • Erratum for Velasco-de Andrés et al., "The Lymphocytic Scavenger Receptor CD5 Shows Therapeutic Potential in Mouse Models of Fungal Infection". 
  • In vitro manogepix susceptibility testing of South African Emergomyces africanus, Emergomyces pasteurianus, and Blastomyces emzantsi clinical isolates. 
  • Semi-mechanistic population pharmacokinetic/pharmacodynamic modeling of a Plasmodium elongation factor 2 inhibitor cabamiquine for prevention and cure of malaria. 
  • Epidemiology and impact of methicillin-sensitive Staphylococcus aureus with β-lactam antibiotic inoculum effects in adults with cystic fibrosis. 
  • Genome-scale analysis of essential gene knockout mutants to identify an antibiotic target process. 
  • A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease. 
  • Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis. 
  • Isavuconazole use and TDM in real-world pediatric practice. 
  • Geographical emergence of sulfadoxine-pyrimethamine drug resistance-associated P. falciparum and P. malariae alleles in co-existing Anopheles mosquito and asymptomatic human populations across Cameroon. 
  • Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections. 
  • Profiling daptomycin resistance among diverse methicillin-resistant Staphylococcus aureus lineages in China. 
  • A phase I study of the safety, tolerability, and pharmacokinetics of contezolid acefosamil after intravenous and oral administration in healthy Chinese subjects. 
  • Safety of early oral ambulatory treatment of adult patients with bloodstream infections discharged from the emergency department. 
  • Plasmid-encoded VCC-1 β-lactamase in a clinical isolate of Aeromonas caviae. 
  • In vitro activity of imipenem/relebactam against Pseudomonas aeruginosa isolated from patients with cystic fibrosis. 
  • Pharmacokinetics and safety of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum: results from IMPAACT P1026s. 
  • Resistance development in Escherichia coli to delafloxacin at pHs 6.0 and 7.3 compared to ciprofloxacin. 
  • Leveraging stewardship to promote ceftriaxone use in severe infections with low- and no-risk AmpC Enterobacterales. 
  • Population pharmacokinetic model of cefepime for critically ill adults: a comparative assessment of eGFR equations. 
  • Simplified urine-based method to detect rifampin underexposure in adults with tuberculosis: a prospective diagnostic accuracy study. 
  • Ciprofloxacin in combination with bacteriophage cocktails against multi-drug resistant Pseudomonas aeruginosa in ex vivo simulated endocardial vegetation models. 
  • Antitoxin MqsA decreases antibiotic susceptibility through the global regulator AgtR in Pseudomonas fluorescens. 
  • The role of rifampicin within the treatment of Mycobacterium avium pulmonary disease. 
  • Emergence of ciprofloxacin- and penicillin-resistant Neisseria meningitidis isolates in Japan between 2003 and 2020 and its genetic features. 
  • A truncated HIV Tat demonstrates potent and specific latency reversal activity. 
  • Routine ophthalmologic examination in Klebsiella pneumoniae bacteremia is not necessary: incidence of and risk factors for ocular involvement. 
  • Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2. 
  • Phage-antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa in in vitro static and dynamic biofilm models. 
  • Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase. 
  • Optimizing anidulafungin exposure across a wide adult body size range. 
  • Dolutegravir pharmacokinetics in Ugandan patients with TB and HIV receiving standard- versus high-dose rifampicin. 
  • Unexpectedly low drug exposures among Ugandan patients with TB and HIV receiving high-dose rifampicin. 
  • Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity. 
  • Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of Acinetobacter baumannii. 
  • Phage-induced bacterial morphological changes reveal a phage-derived antimicrobial affecting cell wall integrity. 
  • Could an optimized joint pharmacokinetic/pharmacodynamic target attainment of continuous infusion ceftazidime-avibactam be a way to avoid the need for combo therapy in the targeted treatment of deep-seated DTR Gram-negative infections? 
  • Comparison of treatment outcomes between intermittent and daily regimens in non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease in relation to sputum smear results: a retrospective cohort study. 
  • β-(1→3)-D-glucan- and mannan-guided early termination of antifungal therapy in ICU patients: a randomized controlled study. 
  • Two different types of tandem sequences mediate the overexpression of TinCYP51B in azole-resistant Trichophyton indotineae. 
  • Safety and pharmacokinetics of SPR206 in subjects with varying degrees of renal impairment. 
  • Case Commentary: An espresso, a free puppy, and multidrug-resistant Campylobacter. 
  • Comparison of contemporary invasive and non-invasive Streptococcus pneumoniae isolates reveals new insights into circulating anti-microbial resistance determinants. 
  • Community spread of a human monkeypox virus variant with a tecovirimat resistance-associated mutation. 
  • Antibacterial efficacy of an ultra-short palmitoylated random peptide mixture in mouse models of infection by carbapenem-resistant Klebsiella pneumoniae. 
  • Effect of malate on the activity of ciprofloxacin against Pseudomonas aeruginosa in different in vivo and in vivo-like infection models. 
  • A novel virulence plasmid encoding yersiniabactin, salmochelin, and RmpADC from hypervirulent Klebsiella pneumoniae of distinct genetic backgrounds. 
  • Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity. 
  • bla KPC-2 overexpression and bla GES-5 carriage as major imipenem/relebactam resistance mechanisms in Pseudomonas aeruginosa high-risk clones ST463 and ST235, respectively, in China. 
  • Pharmacokinetics and safety of a single dose of telavancin in pediatric subjects 2-17 years of age. 
  • Antibiotics do not induce expression of acrAB directly but via a RamA-dependent pathway. 
  • The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus. 
  • Evaluation of in vitro antiviral activity of SARS-CoV-2 Mpro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions. 
  • In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales. 
  • Identification of cpxS mutational resistome in Pseudomonas aeruginosa. 
  • Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model. 
  • Antimicrobial effects of Medicines for Malaria Venture Pathogen Box compounds on strains of Neisseria gonorrhoeae. 
  • Examining the activity of cefepime-taniborbactam against Burkholderia cepacia complex and Burkholderia gladioli isolated from cystic fibrosis patients in the United States. 
  • Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient. 
  • Failure of mecA/mecC PCR Testing to Accurately Predict Oxacillin Resistance in a Patient with Staphylococcus aureus Infective Endocarditis. 
  • Successful Use of Cefepime-Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant New Delhi Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Infection in an Adult Patient with Acute T-Cell Leukemia. 
 
 

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