MINNEAPOLIS — Brandon Workman blew a save opportunity in the eighth inning. Hector Velazquez blew a save opportunity in the 13th.
The Red Sox, meanwhile, squandered perfect opportunities to take the lead in the 10th, 14th and 16th innings.
The Twins eventually won in the 17th inning.
It marked the longest game in Target Field history. Minnesota beat Boston 4-3 in 5 hours, 45 minutes.
Mookie Betts, who has struggled in June with a .210 batting average and .387 slugging percentage entering Tuesday, belted the go-ahead home run in the 13th inning to put Boston ahead 3-2.
Betts connected on a 92.3 mph two-seam fastball from Twins reliever Mike Morin and sent it 380 feet with a 105 mph exit velocity over the wall in left field.
But Max Kepler tied the game in the bottom of the 13th inning with a 391-foot home run to right field.
Brian Johnson — who started Sunday and was expected to start again Saturday — took the loss. He relieved Velazquez, who appeared to leave with an injury. Luis Arraez singled. Eddie Rosario doubled. Kepler singled home the game-winning run.
The Red Sox went 1-for-13 with runners in scoring position and left 14 men on base.
Sox squander chances in 10th, 14th, 16th innings
The Red Sox had excellent chances to take the lead in the 10th, 14th and 16th innings.
Brock Holt doubled to begin the 10th and advanced to third base on Michael Chavis’ groundout. Jackie Bradley Jr. reached first on a hit by pitch. But Christian Vazquez’s 239-foot fly ball to right wasn’t deep enough to score the go-ahead run. Mookie Betts then flied out to deep right to end the frame.
Holt and Chavis singled to lead off the 14th. Both advanced into scoring position on Bradley’s bunt. But Vazquez popped out to second base and Andrew Benintendi grounded out to second base after an intentional walk to Betts loaded the bases.
Andrew Benintendi reached third base with no outs in the 16th. He singled, stole second and advanced to third on catcher Mitch Garver’s throwing error. But J.D. Martinez struck out, Rafael Devers grounded out to first and Xander Bogaerts grounded out to third.
Price leaves after 73 pitches
Red Sox starter David Price tossed 5 innings, allowing just one run, four hits and no walks while striking out two. He threw only 73 pitches but reliever Mike Shawaryn took over for him to begin the sixth inning.
Price’s removal from the game was “not injury related,” a Red Sox spokesperson said.
The lefty averaged 93.9 mph with his four-seam fastballs and 93.1 mph with his two-seam fastball, per Baseball Savant.
Devers does damage
The Red Sox took a 1-0 lead in the top of the fourth inning. Mookie Betts led off with a single and stole second base. He scored when Devers ripped a two-out single with a 104.9 mph exit velocity past first baseman C.J. Cron.
Devers put the Red Sox ahead 2-1 in the seventh with his 12th home run. His blast had a 97.1 mph exit velocity and traveled 374 mph.
Huge pickoff
Mitch Garver doubled and Nelson Cruz singled to lead off the sixth inning against Shawaryn. But Christian Vazquez picked Garver off third base for a very important first out.
Bradley with another leaping catch
Jackie Bradley Jr. took extra bases away from Jorge Polanco with a leaping catch into the center field wall to end the seventh inning.