Buffalo Bills at Tennessee Titans odds, picks and best bets
After being delayed due to a COVID-19 outbreak, the Buffalo Bills (4-0) and Tennessee Titans (3-0) will finally square off Tuesday night at Nissan Stadium in Nashville, with kickoff set for 7 p.m. ET. Here, we analyze the Bills-Titans Week 5 matchup, including the betting odds, spread and lines, and look at the best NFL betting options.
Bills at Titans betting odds and lines
Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated at 9:48 a.m. ET.
- Money line : Bills -185 (bet $185, win $100) | Titans +150 (bet $100, win $150)
- Against the spread/ATS : Bills -3.5 (-106) | Titans +3.5 (-115)
- Over/Under : 51.5 (O: -115, U: -106)
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Bills at Titans game notes
- The Bills and Titans both rank outside the top 20 in passing yards allowed per game. Tennessee is also 31st in rushing yards allowed per game (166.0).
- Tennessee is allowing the second-most yards per play on defense.
- The Bills are 4-6 in their last 10 meetings with the Titans, but the series is split 5-5 ATS.
- The total is 3-0-1 in the Bills' four games this season. The Titans are 2-1 against the Over/Under.
- The Titans have yet to cover the spread this season, going 0-3. Buffalo is 3-1 ATS.
Bills at Titans key injuries
Bills
- LB Matt Milano (pec) out
- WR John Brown (knee) questionable
- OT Cody Ford (groin) questionable
- RB Zack Moss (toe) questionable
- CB Tre'Davious White (back) questionable
Titans
- OT Taylor Lewan (shoulder) questionable
- WR A.J. Brown (knee) questionable
Bills at Titans: Odds, betting lines, picks and prediction
Prediction
Bills 27, Titans 23
Money line ( ?)
This is bound to be a close game, but I like the BILLS (-185) to win outright. QB Josh Allen has been a stud all year, the defense has yet to hit its stride and Moss should be back to complement RB Devin Singletary in the backfield.
Tennessee's defense will give up too many big plays to Buffalo and has been susceptible to opposing passing attacks all year. The Bills will win a close one.
Against the spread ( ?)
The Titans failed to cover the spread in their first three games of the year, which is important to note. Yes, they're undefeated in the standings, but Tennessee hasn't been all that impressive against three lesser opponents.
The Titans won their three games by a total of six points. It's hard to take the favorites in a game where their opponent plays such tight contests, but I'm taking the BILLS -3.5 (-106) to cover the 3.5-point margin and win by at least 4 points.
Over/Under ( ?)
At 51.5 points, the Over/Under feels high. Although the total has gone Over in five of their seven combined games this season, this is a matchup where it will come in just Under the 53.5-point total.
As explosive as the Buffalo offense is, Tennessee is going to shorten the game with its rushing attack and take possessions away from Buffalo. I like the UNDER 51.5 (-115) in this one.
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