Award Abstract # 1647837
Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
NSF Org: |
EEC
Div Of Engineering Education and Centers
|
Recipient: |
TRUSTEES OF BOSTON UNIVERSITY
|
Initial Amendment Date: |
September 8, 2017 |
Latest Amendment Date: |
September 20, 2023 |
Award Number: |
1647837 |
Award Instrument: |
Cooperative Agreement |
Program Manager: |
Randy Duran
rduran@nsf.gov
(703)292-5326
EEC
Div Of Engineering Education and Centers
ENG
Directorate For Engineering
|
Start Date: |
October 1, 2017 |
End Date: |
September 30, 2027 (Estimated) |
Total Intended Award Amount: |
$19,750,000.00 |
Total Awarded Amount to Date: |
$32,524,446.00 |
Funds Obligated to Date: |
FY 2017 = $3,500,000.00
FY 2018 = $7,587,511.00
FY 2019 = $950,561.00
FY 2020 = $5,154,126.00
FY 2021 = $4,368,248.00
FY 2022 = $7,640,481.00
FY 2023 = $3,219,519.00
|
History of Investigator: |
-
David
Bishop
(Principal Investigator)
djb1@bu.edu
-
Christopher
Chen
(Co-Principal Investigator)
-
Arvind
Agarwal
(Co-Principal Investigator)
-
Alice
White
(Co-Principal Investigator)
-
Brendon
Baker
(Co-Principal Investigator)
-
Stephen
Forrest
(Former Co-Principal Investigator)
|
Recipient Sponsored Research Office: |
Trustees of Boston University
1 SILBER WAY
BOSTON
MA
US
02215-1703
(617)353-4365
|
Sponsor Congressional District: |
07
|
Primary Place of Performance: |
Trustees of Boston University
MA
US
02215-1300
|
Primary Place of Performance Congressional District: |
07
|
Unique Entity Identifier (UEI): |
THL6A6JLE1S7
|
Parent UEI: |
|
NSF Program(s): |
RES EXP FOR TEACHERS(RET)-SITE, ERC-Eng Research Centers
|
Primary Program Source: |
01002223DB NSF RESEARCH & RELATED ACTIVIT
01002324DB NSF RESEARCH & RELATED ACTIVIT
01001718DB NSF RESEARCH & RELATED ACTIVIT
01001819DB NSF RESEARCH & RELATED ACTIVIT
01001920DB NSF RESEARCH & RELATED ACTIVIT
01002021DB NSF RESEARCH & RELATED ACTIVIT
01002122DB NSF RESEARCH & RELATED ACTIVIT
|
Program Reference Code(s): |
102Z,
113E,
115E,
116E,
123E,
124E,
129E,
131E,
1480,
7218,
7633,
7680,
9177,
9178
|
Program Element Code(s): |
135900,
148000
|
Award Agency Code: |
4900
|
Fund Agency Code: |
4900
|
Assistance Listing Number(s): |
47.041
|
ABSTRACT
Heart disease is the number one cause of death in the US and a leading cause worldwide, but current medicine cannot regenerate and or repair diseased human heart tissue. Today, there is no cure for a heart attack. The vision of Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision (CELL-MET) Nanosystems Engineering Research Center is to change this. CELL-MET will develop tissue-engineering principles to create scalable, low-cost technologies for growing clinically significant cardiac tissues from cell-level building blocks. The research approach is to adapt and advance novel nanomanufacturing techniques to integrate a variety of functional biological structures and elements into flexible polymer scaffolds that support and guide heart cells. The goal of this project is to create cardiac patches that will someday allow for the repair of hearts damaged by a heart attack or other diseases. In addition to their potential for repairing damaged hearts, artificial cardiac tissues will be used to test the effects of heart drugs or other drugs more realistically and efficiently than is currently possible. Broader impacts will include kindergarten to post-doctoral education and training programs that will produce a diverse, well-trained, world aware workforce to support the new billion dollar industries enabled by CELL-MET research. Industrial partners will work with CELL-MET to create these new industries, developing the business opportunities generated by the research breakthroughs.
CELL-MET aims to create functional, clinically significant heart tissue in the laboratory by controlling the cardiac structure across different length scales. At sizes smaller than a micron and up to the ten micron scale of cells, CELL-MET will align heart muscle cells (cardiomyocytes) and connect them to one another via special cellular structures, enabling them to contract and relax in synchrony. At the multicellular scale, it will monitor and control chemical signaling both among these cells and between them and supporting cells. At the scale of tissue constructs, CELL-MET will create highly structured networks of blood vessels lined with epithelial cells, which are needed for any thick tissue. The ten-year vision encompasses the incorporation of endocardial cells that help define the large-scale structure and electrophysiological function of the heart, as well as the valves that ensure unidirectional blood flow.
CELL-MET brings together a diverse, world-class team from Boston University, the University of Michigan, Florida International University, Harvard, Columbia, Argonne National Lab, EPFL (Switzerland), and Centro Atomico-Bariloche (Argentina). The team has expertice in semiconductors, photonics, nanotechnology, optical systems, organic molecules, cardiac biology, and cellular assembly. CELL-MET is uniquely positioned to harness the capabilities and synergies among these disciplines. CELL-MET plans to combine novel techniques for patterning molecules on the scale of 50 nm or less with nanometer resolution 3D-printed scaffolds. 3D nanoprinting technologies will produce scaffolds that Atomic Calligraphy and Organic Vapor Jet Printing will write upon to create the focal adhesion points, the places that attach the cells. Advanced tissue engineering techniques will populate these nanostructures with cardiomyocytes and other cardiac cell types to produce the living tissues.
As CELL-MET advances the technology, it will work with commercial members of its Innovation Ecosystem to create entirely new industries. Through its Education and Workforce Development programs, CELL-MET will recruit and train a diverse, world aware workforce to support the industries that it creates.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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ChemElectroChem
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Shain, William J. and Vickers, Nicholas A. and Negash, Awoke and Bifano, Thomas and Sentenac, Anne and Mertz, Jerome
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Nautiyal, Pranjal and Boesl, Benjamin and Agarwal, Arvind
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Guo, Jing and Pan, Jie and Chang, Shuai and Wang, Xuewen and Kong, Na and Yang, Wenrong and He, Jin
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Badon, Amaury and Mertz, Jerome
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Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
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10.1364/BRAIN.2018.BF4C.5
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Ronaldson-Bouchard, Kacey and Vunjak-Novakovic, Gordana
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del Corro, Pablo G. and Imboden, Matthias and Pérez, Diego J. and Bishop, David J. and Pastoriza, Hernán
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Chang, Jackson and Holyoak, Michael and Kannell, George and Beacken, Marc and Imboden, Matthias and Bishop, David J.
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arXiv.org
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Ronaldson-Bouchard, Kacey and Ma, Stephen P. and Yeager, Keith and Chen, Timothy and Song, LouJin and Sirabella, Dario and Morikawa, Kumi and Teles, Diogo and Yazawa, Masayuki and Vunjak-Novakovic, Gordana
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Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optical Society of America, 2018)
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10.1364/BRAIN.2018.BW2C.6
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Liu, Bohao and Lee, Benjamin W. and Nakanishi, Koki and Villasante, Aranzazu and Williamson, Rebecca and Metz, Jordan and Kim, Jinho and Kanai, Mariko and Bi, Lynn and Brown, Kristy and Di Paolo, Gilbert and Homma, Shunichi and Sims, Peter A. and Topkara,
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Weber, Timothy D. and Mertz, Jerome
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Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optical Society of America, 2018)
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10.1364/TRANSLATIONAL.2018.CF3B.8
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Shain, William J. and Vickers, Nicholas A. and Li, Jiang and Han, Xue and Bifano, Thomas and Mertz, Jerome
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Reeves, Jeremy B. and Jayne, Rachael K. and Stark, Thomas J. and Barrett, Lawrence K. and White, Alice E. and Bishop, David J.
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Nano Letters
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" Emerging Impact of Extracellular Vesicles on Tissue Engineering and Regeneration"
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Christopher, Jason W. and Vutukuru, Mounika and Lloyd, David and Bunch, J. Scott and Goldberg, Bennett B. and Bishop, David J. and Swan, Anna K.
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10.1002/cphg.52
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Tong, Lin and Mozneb, Maedeh and Bravo, Elisa and Ferrando, Victoria and Li, Chen-Zhong
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TrAC Trends in Analytical Chemistry
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10.1016/j.trac.2019.05.021
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Steier, Anke and Muñiz, Ay?e and Neale, Dylan and Lahann, Joerg
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Advanced Engineering Materials
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10.1002/adem.201900085
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Javor, Josh and Yao, Zhancheng and Imboden, Matthias and Campbell, David K. and Bishop, David J.
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Kumar, Ramya and Kratzer, Domenic and Cheng, Kenneth and Prisby, Julia and Sugai, James and Giannobile, William V. and Lahann, Joerg
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