"Two of the genes which are thought to have the largest impact are CYP1A2 and ADORA2A. Caffeine metabolism is mainly determined by the cytochrome enzyme P-450 1A2 (CYP1A2)," Clarke said.

After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 ...

In particular, you should avoid taking Veozah if you're taking CYP1A2 inhibitors because they increase the levels of Veozah ...

Potentiated by potent CYP1A2 inhibitors (eg, cimetidine, fluvoxamine, quinolones, enoxacin): avoid. May potentiate or be potentiated by CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine ...

Max 2403mg/day. Dose modifications: see full labeling. Concomitant strong CYP1A2 inhibitors (eg, fluvoxamine, enoxacin): 267mg 3 times daily. Concomitant moderate CYP1A2 inhibitors (eg ...

Dr Grimaldi says if you carry the genetic variation CYP1A2 (AA), for example, you will “almost certainly” metabolise caffeine faster than someone who doesn’t, and therefore feel its effects ...

When metabolism of cinacalcet in the liver by CYP1A2 is inhibited by fluvoxamine and ciprofloxacin, or enhanced by tobacco smoking, cinacalcet dose should be decreased or increased, respectively.

When the editorial board of BJPsych International acceded to the launch of a web-based monthly arts blog, I volunteered as the commissioning editor. I did this partly because I already straddled the ...

The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem. 2010 Nov ...

UCB (Euronext Brussels: UCB), a global biopharmaceutical company, today announced the latest research from its expansive neurology portfolio and pipeline to be presented at the 76th American Academy ...