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Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
As BACE2 is a homologous protein, most inhibitors tested in clinical trials also cross-inhibit the (pro-amyloidogenic) ...
Active control of broadband sound through the open aperture of a full-sized domestic window
Shutting the window is usually the last resort in mitigating environmental noise, at the expense of natural ventilation. We ...
The earliest domestic cat on the Silk Road
We present the earliest evidence for domestic cat (Felis catus L., 1758) from Kazakhstan, found as a well preserved skeleton ...
Early detection and classification of live bacteria using time-lapse coherent imaging and deep learning
A novel automated system quickly detects and classifies live bacteria in water by using deep neural networks to analyze ...
Monitoring the charge-transfer process in a Nd-doped semiconductor based on photoluminescence and SERS technology
This study provides a new way to naturally eliminate the SERS fluorescence background by doping with Nd ions. These ...
‘Concussion’ is not a true diagnosis
In current usage, ‘concussion’ describes a clinical presentation, but does not identify the underlying pathological process ...
Design and flight results of the VHF/UHF communication system of Longjiang lunar microsatellites
Satellites with amateur radio communication capabilities have not been operated in lunar orbit before. Here, the authors ...
The many roads to the red planet — a memoir
As three nations prepare to send spacecraft to Mars, a planetary scientist offers her personal tour of those who led the way.
Educating military primary health-care providers in genomic medicine: lessons learned from the MilSeq Project
With few trained genetics professionals, the Military Health System is ill-equipped to manage the rapid expansion of genomic ...
Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication
We read with great interest the correspondence in Lancet by Marinho et al.  describing purported retinal manifestations of ...
Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation
Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition, which is characterized by vasculogenic ...
This material is almost as hard as diamond — but as light as graphite
A new addition to the carbon family, pentadiamond, is predicted to be light like graphite, hard like diamond and ...