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  1. Genomic profiling of subcutaneous patient-derived xenografts …

    • Childhood cancers represent about 1% of newly diagnosed cancer cases in the US. Though rare, cancer is the leading cause of disease-related death in children1. More than 60% of childhood cancer ca… See more

    Abstract

    Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer … See more

    Nature
    Results

    Overview of patient samples, PDXs, and genomic data
    We generated 90 subcutaneous PDXs from 194 fresh solid tumor samples using a previously … See more

    Nature
    Discussion

    Solid tumors are rare in children; the rarity poses a significant challenge for building resources at scale. Preserving tumor tissue in rodents is essential for preclinical and mechanisti… See more

    Nature
    Methods

    Sample collection and patient consent
    This study complies with all relevant ethical regulations. It was approved by the Institutional Review Board (IRB) and the Institutiona… See more

    Nature
    Data availability

    The raw sequencing data generated in this study have been deposited in the European Genome-Phenome Archive database under accession code EGAS00001006710 [https://eg… See more

    Nature
    Acknowledgements

    We thank Kathryn Bondra, Fuyang Li, Vanessa DelPozo, Samson Ghilu, and Edward Favors for technical assistance with sample preparation and animal work. We thank … See more

    Nature
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  1. Funan He - Postdoctoral Researcher - UT Health SA, Greehey CCRI

  2. ‪Funan He‬ - ‪Google Scholar‬

  3. Genomic profiling of subcutaneous patient-derived xenografts …

  4. Integrative Analysis of Somatic Mutations in Non-coding Regions ...

  5. The phylogenetic relationship within SARS-CoV-2s: An expanding …

  6. Comparative Transcriptome Analyses Reveal the Role of Conserved ...

  7. The Impact of DNA Methylation Dynamics on the Mutation Rate …

  8. Zheng Lab - Greehey Children's Cancer Research Institute

  9. Funan - Wikipedia

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