Bacterial infections trigger a wide range of host cell responses. For the interaction of Pseudomonas aeruginosa and epithelial cells it is known that transcription factor NF-kappaB plays a central role, but its effects have to be specified by cooperation

NF-kB (Nuclear factor kappa beta) is one of the signal transduction pathways. The pathway is a conserved prototypical proinflammatory Signalling pathway which is associated with the expression of proinflammatory genes. NF-kB is a heterodimeric protein

Background Accurate recognition of regulatory elements in promoters is an essential prerequisite for understanding the mechanisms of gene regulation at the level of transcription. Composite regulatory elements represent a particular type of such