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Hey there. Today, we learn about how scientists had a happenstance discovery about tumor-suppressor genes and used them to target aggressive pediatric tumor cells. We see a U.K. health agency make a controversial call about an ALS drug made by Biogen, and more.
The need-to-know this morning
- Biogen and Eisai‘s FDA application for a subcutaneous version of the Alzheimer’s drug Leqembi has been delayed. The FDA has asked for three months of immunogenicity data and a Fast Track designation-specific application.
A genetic clue to suppressing a fatal childhood tumor
Most cancers are able to proliferate because the “tumor suppressor” genes meant to keep cell growth in check are dysfunctional. But researchers recently chanced upon a way to treat these sorts of cancers, focusing in vitro on a rare and aggressive childhood cancer called rhabdoid tumors. Researchers were able to fix a broken tumor suppressor system, turning malignant cells back into ordinary ones. The approach is still far from clinical trials, but offers a new pathway for scientists to target hard-to-treat cancers.
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