As fentanyl tore across New England, Kelly Ayotte, then a U.S. senator from New Hampshire, introduced legislation to combat the powerful drug. It was September 2015, just months after the DEA issued a “nationwide alert” warning of a fentanyl surge and a spate of deaths in her state, as well as in New Jersey, Pennsylvania, Rhode Island and Missouri.

A former prosecutor and Republican state attorney general who handled myriad drug cases, Ayotte was surprised at fentanyl’s rapid rise. She learned it was being manufactured in China and sent to the United States through the mail or smuggled over the Mexican border before wending its way into the nation’s illicit drug supply.

Rob Portman

Ohio's Rob Portman has served in the Senate since 2011.

Taunton OD

Taunton police officers and paramedics respond to the scene of an apparent overdose outside of a bar in Taunton, Mass.  

Taunton, Mass., detective Thomas Larkin

Taunton, Mass., detective Thomas Larkin searches for drug dealers. The city saw more than five overdoses each week last year, police say.  

Ian Rego

Ian Rego, 25, in his shared room at a treatment center in Fall River, Mass., south of Taunton, after enrolling in a detox program in June. He said he overdosed on fentanyl in a gas station bathroom the day before.  

Sen. Maggie Hassan

Sen. Maggie Hassan, D-N.H.

Rep. Elijah Cummings

Rep. Elijah Cummings is a Democrat from Maryland.  

Rep. Greg Walden

Rep. Greg Walden is a Republican from Oregon.  

Judi Gilmore

Judi Gilmore lost one son to a heroin overdose in 2006 and another to a fentanyl overdose in 2018.