Peer-Reviewed Publication

https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2023-0020

Announcing a new article publication for BIO Integration journal.   This study was aimed at exploring the causal relationships of four sarcopenia-related traits (appendicular lean mass, usual walking pace, right hand grip strength, and levels of moderate to vigorous physical activity) with body mass index (BMI) and ovarian cancer risk, by using univariable and multivariable Mendelian randomization (MR) methods.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0022

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Immediate recurrence (Im-Recurr), a type of atrial fibrillation (AF) recurrence occurring during the blanking period after radiofrequency catheter ablation (RFCA), has received little attention. Therefore, this study was aimed at exploring the clinical significance of Im-Recurr in patients with AF after RFCA.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0023

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Observational studies have indicated an association between the gut microbiota and the occurrence and progression of aortic aneurysm (AA). However, the causal relationship between the gut microbiota and AA and its subtypes remains unclear. This study used Mendelian randomization (MR) to gain new insights into the relationship between the gut microbiota and AA, including AA subtypes.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0021

Announcing a new article publication for Cardiovascular Innovations and Applications journal.   Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both age-related conditions and cardiovascular disorders. This research was aimed at examining the link between MMA and abdominal aortic calcification (AAC).

https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2024-0002

Announcing a new article publication for BIO Integration journal.   Cancer remains a major global health burden, necessitating innovative approaches for improved diagnosis and treatment. Aptamer-based theranostics have gained attention in the field of cancer research and treatment. Aptamers can be used as targeting ligands for the delivery of therapeutic agents to cancer cells, as well as for the detection and imaging of cancer, due to high binding affinity and selectivity.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0008

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Coronary microembolization (CME) occurs in patients with acute coronary syndrome and is caused primarily by atherosclerotic plaque rupture associated with surgery. CME can lead to arrhythmias, decreased coronary blood flow reserve, and cardiac systolic dysfunction.

Researchers at the University of Nottingham have created an endoscopic device that can 3D image the stiffness of individual biological cells and complex organisms, a discovery that could help doctors discover and treat cancer earlier.  

 

In its early stages, cancer cells are, far softer than normal cells. This allows them to squeeze through tight gaps and rapidly spread throughout the body – known as metastasis. During this process, collections of cells modify their surrounding environment to create stiff tumours that protect them from outside threats.  

 

Published in Nature Communications Biology, the new technology can measure the stiffness of these individual cells with a hair-thin endoscopic probe, meaning it will be possible to perform histology (i.e. investigating microscopic cellular tissue) based on abnormal stiffness at the single cell level inside the human body for the first time.